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Abstract #0700

In vivo imaging of human Locus coeruleus at 3 and 7 Tesla

Nikos Priovoulos1, Heidi IL Jacobs1,2, Dimo Ivanov2, Kamil Uludag2, Frans Verhey1, and Benedikt A Poser2

1Faculty of Health and Medicine, Maastricht University, Maastricht, Netherlands, 2Faculty of Physhology and Neuroscience, Maastricht University, Maastricht, Netherlands

Structural and functional alterations of the Locus coeruleus (LC) are implicated in various neurological diseases, including Alzheimer’s. Current standard spin-echo based approaches to imaging the LC suffer from several limitations at 3T, including long acquisition time and highly anisotropic resolution. In this study, we have evaluated in healthy human subjects different MRI contrasts both at 3 and 7 Tesla to image LC. We show that visualization of the locus coeruleus is best achieved with magnetization transfer contrast at 7T superior to standard T1- and T2-weighted methods.

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