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Abstract #0711

Volumetric 3D analysis of high grade glioma at pre- and post-radiation therapy by magnetic resonance echo-planar spectroscopic imaging

Yanqin Lin1, Doris Lin2, Karim Snoussi2, Anouk Marsman2, Andrew A. Maudsley3, Sulaiman Sheriff3, Katie Link2, Peter B. Barker2,4, and Lawrence Kleinberg5

1Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, 2Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Radiology, University of Miami, Miami, FL, United States, 4F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

31 patients with high grade glioma were recruited at both pre- and post-radiation therapy. 3D EPSI was employed on a Siemens 1.5 T scanner. NAA and Cho in lesion are normalized to Cr at contralateral part. At pre-radiation, Cho/Cr at lesion is significantly higher than that in contralateral part (p = 0.003). From pre- to post-radiation, Cho/Cr at lesion is significantly decreased (p < 0.007). Elevated Cho level can be an indicator for residual glioma tumor after surgery. Cho/Cr ratio can be used to monitor the treatment response. EPSI technique can be a promising way to monitor treatment response.

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