Abstract #0711

Volumetric 3D analysis of high grade glioma at pre- and post-radiation therapy by magnetic resonance echo-planar spectroscopic imaging

Yanqin Lin¹, Doris Lin², Karim Snoussi², Anouk Marsman², Andrew A. Maudsley³, Sulaiman Sheriff³, Katie Link², Peter B. Barker^2,4, and Lawrence Kleinberg⁵

¹Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, ²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Radiology, University of Miami, Miami, FL, United States, ⁴F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

31 patients with high grade glioma were recruited at both pre- and post-radiation therapy. 3D EPSI was employed on a Siemens 1.5 T scanner. NAA and Cho in lesion are normalized to Cr at contralateral part. At pre-radiation, Cho/Cr at lesion is significantly higher than that in contralateral part (p = 0.003). From pre- to post-radiation, Cho/Cr at lesion is significantly decreased (p < 0.007). Elevated Cho level can be an indicator for residual glioma tumor after surgery. Cho/Cr ratio can be used to monitor the treatment response. EPSI technique can be a promising way to monitor treatment response.

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