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Abstract #0712

Differentiating Recurrent Glioma from Treatment Effects Using Amide Proton Transfer-Weighted MRI

Shanshan Jiang1, Yi Zhang1, Hye-Young Heo1, Peter Van Zijl1,2, and Jinyuan Zhou1,2

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We assess the feasibility and the value of amide proton transfer-weighted (APTw) MRI in identifying viable malignant glioma. 22 patients with suspected recurrent glioma following chemoradiation were scanned at 3T. A total of 64 stereotactic biopsy specimens were obtained from gadolinium-enhancing regions of interest with varying APTw signals, 47 of which were histopathologically assigned as recurrent tumor and 17 treatment effects. APTw MRI revealed different signal intensities in the biopsied sites showing recurrent tumor (hyperintense signal) or treatment effects (iso-intense to minimally hyperintense signal). APTw signal intensity identified recurrent tumor with 97.9% sensitivity and 88.2% specificity.

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