Abstract #0713

Disrupted Integrity of Frontal White Matter and Neurocognitive Correlates in Patients Treated for Pediatric Medulloblastoma

John O Glass¹, Robert J Ogg¹, Jung W Hyun², Julie H Harreld¹, Jane E Schreiber³, Yimei Li², Amar J Gajjar⁴, and Wilburn E Reddick¹

¹Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, United States, ²Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, United States, ³Psychology, St. Jude Children’s Research Hospital, Memphis, TN, United States, ⁴Oncology, St. Jude Children’s Research Hospital, Memphis, TN, United States

This study assessed the longitudinal white matter (WM) microstructure of 146 patients and 72 normal healthy age-similar controls. WM volume, fractional anisotropy (FA), and radial (RAD) and axial (AX) diffusivity trajectories were examined and correlated with neurocognitive performance at 36 months. After surgery but before any additional therapy, frontal WM volume in patients was similar to controls but FA was significantly reduced and was significantly correlated with neurocognitive performance three years later. Over the next three years, WM volume significantly decreased in patients and was significantly correlated with decreased Working Memory.

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