Abstract #0718

Layer-specific analysis of cortical microstructure using in-vivo 7T diffusion MRI

Omer Faruk Gülban¹, Federico De Martino¹, An Thanh Vu², Kamil Ugurbil³, Essa Yacoub³, and Christophe Lenglet³

¹Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ²Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Health Care System, San Francisco, CA, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

We present unique in-vivo human 7T diffusion MRI data and a dedicated layer-specific analysis pipeline. We leverage the high spatial and angular resolution of this dataset to improve cortical fiber orientation mapping (i.e. limit gyral bias and identify fiber crossings), and study axonal trajectories within the cortex across depths.

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