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Abstract #0719

HARDI and oscillating gradient diffusion MRI reveal disrupted embryonic cortical microstructure

Dan Wu1, Wei Shao2,3, Songhai Shi2,3,4, and Jiangyang Zhang5

1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2BCMB Allied Graduate Program, Weill Cornell Graduate School of Medical Sciences, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Graduate Program in Neuroscience, Weill Cornell Graduate School of Medical Sciences, 5Radiology, New York University School of Medicine, NY, United States

We investigated the capability of advanced diffusion MRI, including high-angular resolution diffusion MRI (HARDI) and oscillating gradient diffusion MRI, to characterize cortical microstructural organization in the embryonic mouse brains. HARDI-based tractography revealed reduced axons in the intermediate zone of the embryonic cortex in the Sas-4-/-;p53-/- mice compared to the wildtypes. The oscillating gradient diffusion MRI delineated a three-lamina structure in the cortex of the normal embryonic brain, reflecting the neuronal cell distributions during embryonic brain development, which was altered by mislocalized RGPs in extra-ventricular zone, resulting in diminished contrast in the mutant cortex.

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