Abstract #0719

HARDI and oscillating gradient diffusion MRI reveal disrupted embryonic cortical microstructure

Dan Wu¹, Wei Shao^2,3, Songhai Shi^2,3,4, and Jiangyang Zhang⁵

¹Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, ²BCMB Allied Graduate Program, Weill Cornell Graduate School of Medical Sciences, ³Developmental Biology Program, Memorial Sloan Kettering Cancer Center, ⁴Graduate Program in Neuroscience, Weill Cornell Graduate School of Medical Sciences, ⁵Radiology, New York University School of Medicine, NY, United States

We investigated the capability of advanced diffusion MRI, including high-angular resolution diffusion MRI (HARDI) and oscillating gradient diffusion MRI, to characterize cortical microstructural organization in the embryonic mouse brains. HARDI-based tractography revealed reduced axons in the intermediate zone of the embryonic cortex in the Sas-4^-/-;p53^-/- mice compared to the wildtypes. The oscillating gradient diffusion MRI delineated a three-lamina structure in the cortex of the normal embryonic brain, reflecting the neuronal cell distributions during embryonic brain development, which was altered by mislocalized RGPs in extra-ventricular zone, resulting in diminished contrast in the mutant cortex.

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