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Abstract #0720

Mapping of cerebral cortical microstructure characterized by non-Gaussian water diffusion in aging

Qinmu Peng1,2, King Kevin3,4, Minhui Ouyang1, Hanzhang Lu5, and Hao Huang1,2

1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Imaging, Huntington Medical Research Institutes, 4Department of Radiology, University of Texas Southwestern Medical Center, 5Department of Radiology, Johns Hopkins University

The cellular and molecular processes inside the cerebral cortex play a critical role in aging and neurodegenerative disorders. The microstructural changes associated to these cortical processes can be assessed with multi-shell diffusion MRI. Here, we aimed to accurately quantify the regional cortical microstructural changes of the aging brains. Multi-shell diffusion MRI was acquired to measure mean kurtosis (MK) derived from DKI at the center of the cerebral cortical layer for specific cortical regions. Significant MK decreases were found in the primary somatosensory regions, but not in prefrontal and visual regions, suggesting differentiated aging processes in different cortical regions.

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