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Abstract #0723

In vivo observation and interpretation of time dependent diffusion in human gray matter

Antonios Papaioannou1, Dmitry Novikov1, and Els Fieremans1

1Radiology, New York University School of Medicine, Center for Biomedical Imaging, New York, NY, United States

The temporal scaling of the diffusion coefficient and diffusional kurtosis may reveal the underlying microstructural features of the human brain. Here we demonstrate time-dependent diffusion coefficient and kurtosis in gray matter areas of the human brain in vivo. Our results suggest that the major contribution of time-dependence in gray matter originates from intra-neurite water with the main source of restrictions, e.g. dentrites and beads, being short-range disordered in their placement.

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