Diffusion imaging of the human hippocampus is typically limited to low spatial resolution due to challenges with low signal-to-noise ratio. Here we demonstrate error in fractional anisotropy/mean diffusivity in high resolution diffusion imaging acquired with multiple gradient directions and 1 average, which is mitigated by acquiring fewer directions and multiple signal averages. Using this approach, 1x1x1 mm3 diffusion data at 3T is shown to produce mean diffusion weighted images with excellent contrast within the hippocampus, acquired in a clinically feasible scan time of 6 minutes. High resolution diffusion imaging will impact the study of numerous disorders affecting the hippocampus.
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