Abstract #0725

Phase II Clinical Hyperpolarized 13C 3D-Dynamic Metabolic Imaging of Prostate Cancer using a B1-insensitive Variable Flip Angle Design

Hsin-Yu Chen^1,2, Peder E.Z. Larson^1,2, Jeremy W. Gordon¹, Robert A. Bok¹, Marcus Ferrone³, Mark van Criekinge¹, Lucas Carvajal¹, Rahul Aggarwal⁴, James B. Slater¹, Ilwoo Park¹, Eugene Milshteyn^1,2, Sarah J. Nelson^1,2, John Kurhanewicz^1,2, and Daniel B. Vigneron^1,2

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²UCSF/UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, ³Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, United States, ⁴School of Medicine, University of California, San Francisco, San Francisco, CA, United States

The 3D compressed-sensing echo-planar spectroscopic imaging (CS-EPSI) sequence has enabled 5-dimensional HP-¹³C imaging of human prostate cancer with full-prostate coverage and high spatial and temporal resolution. A new variable flip angle design substantially desensitizes the sequence to B₁ variations for improved quantitative analysis of pyruvate-to-lactate rate constant (k_PL) measurements. Pre-clinical animal and clinical patient studies demonstrate that the resulting sequence enabled improved quantitative accuracy while maintaining excellent metabolite SNR.

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