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Abstract #0726

Demonstrating the Randle Cycle In Vivo: Assessment of Physiological Alterations in Human Cardiac Metabolism Using Hyperpolarised 13C MR Spectroscopy

Damian Tyler1, Oliver Rider2, Michael Dodd1, Angus Lau3, Andrew Lewis2, Jack Miller1,4, Mark Peterzan2, Claire Trumper1, and Stefan Neubauer2

1Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Physical Sciences, Sunnybrook Research Institute, Toronto, Canada, 4Department of Physics, University of Oxford, Oxford, United Kingdom

The recent introduction of dissolution Dynamic Nuclear Polarization (DNP) has opened up a new window on in vivo metabolism and in this work we present the first demonstration that dissolution-DNP can observe physiological modulation of metabolism in the healthy human heart. The transition from the fasted to the fed state is shown to lead to an increase in flux through the key regulatory enzyme, pyruvate dehydrogenase, due to a metabolic switch away from fatty acid oxidation towards glucose oxidation. Such studies will provide the basis for future clinical studies exploring the metabolic alterations that occur in the diseased heart.

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