The recent introduction of dissolution Dynamic Nuclear Polarization (DNP) has opened up a new window on in vivo metabolism and in this work we present the first demonstration that dissolution-DNP can observe physiological modulation of metabolism in the healthy human heart. The transition from the fasted to the fed state is shown to lead to an increase in flux through the key regulatory enzyme, pyruvate dehydrogenase, due to a metabolic switch away from fatty acid oxidation towards glucose oxidation. Such studies will provide the basis for future clinical studies exploring the metabolic alterations that occur in the diseased heart.
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