Abstract #0728

Human Hyperpolarized C-13 MRI Using a Novel Echo-Planar Imaging (EPI) Approach

Jeremy W Gordon¹, Hsin-Yu Chen¹, Peder EZ Larson¹, Ilwoo Park¹, Mark Van Criekinge¹, Eugene Milshteyn¹, Robert Bok¹, Rahul Aggarwal², Marcus Ferrone³, James B Slater¹, John Kurhanewicz¹, and Daniel B Vigneron¹

¹Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Medicine, UCSF, San Francisco, CA, United States, ³Clinical Pharmacy, UCSF, San Francisco, CA, United States

In this pilot study, we developed and applied a specialized symmetric EPI approach for the study of hyperpolarized [1-¹³C]pyruvate metabolism in the human prostate. We show that this approach can acquire ghost-free hyperpolarized [1-¹³C]pyruvate and [1-¹³C]lactate images with high spatiotemporal resolution in a clinical setting.

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