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Abstract #0729

In Vivo Visualization of Orbital Immune Cell Infiltration During Early Development of Graves’ Disease by 19F MRI

Ulrich Flögel1, Anja Eckstein2, and Utta Berchner-Pfannschmidt3

1Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany, 2Ophthalmic Clinic, University Hospital Essen, 3Molecular Ophthalmology, University Hospital Essen

Graves’ disease is an antibody-mediated autoimmune condition of the thyroid gland, which is frequently associated with Graves’ orbitopathy (GO), where inflammation of the orbit results in a detrimental remodeling of the orbital soft tissue. To investigate the molecular basis of GO and evaluate new therapeutic targets for treatment, we used a recently established mouse model of GO and analyzed the interplay of inflammation and adipogenesis using anatomical 1H MRI and 19F MRI for immune cell tracking. Hereby, the infiltration of immune cells could be identified as initial step leading to the remodeling of the orbital soft tissue in GO mice.

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