Graves’ disease is an antibody-mediated autoimmune condition of the thyroid gland, which is frequently associated with Graves’ orbitopathy (GO), where inflammation of the orbit results in a detrimental remodeling of the orbital soft tissue. To investigate the molecular basis of GO and evaluate new therapeutic targets for treatment, we used a recently established mouse model of GO and analyzed the interplay of inflammation and adipogenesis using anatomical 1H MRI and 19F MRI for immune cell tracking. Hereby, the infiltration of immune cells could be identified as initial step leading to the remodeling of the orbital soft tissue in GO mice.
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