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Abstract #0734

Detection of tumor hypoxic region using pH-activatable nanoparticles containing manganese contrast agent

Daisuke Kokuryo1,2, Peng Mi3,4,5, Horacio Cabral6, Tsuneo Saga1, Ichio Aoki1, Nouhiro Nishiyama3,4, and Kazunori Kataoka4,6,7

1Department of Molecular Imaging and Theranostics, National Institute for Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Graduate School of System Informatics, Kobe University, Kobe, Japan, 3Institute of Innovative Research, Tokyo Institute of Technology, Japan, 4Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industry Promotion, Kawasaki, Japan, 5State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, People's Republic of China, 6Graduate School of Engineering, The University of Tokyo, Japan, 7Graduate School of Medicine, The University of Tokyo, Japan

Assessing the environment inside a tumor would aid the development of an effective therapeutic strategy. Our group has recently developed a pH-activatable nanoparticle containing MR contrast agents, which is called MnCaP micelle. For an in vivo tumor model, a specific and strong enhancement of MR signal in the tumor was obtained after the administration. The enhanced area was agreed with the high lactate region found with 1H-MRS and which corresponds to the hypoxic region inside tumor. We conclude that MnCaP micelle detects hypoxic regions in the tumor clearly and therefore it has potential to provide important information for tumor therapy.

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