Abstract #0733

CEST MRI of PSMA expression using natural dextran-based contrast agents

Guanshu Liu^1,2, Sangeeta Ray Banerjee², Xing Yang², Nirbhay Yadav¹, Ala Lisok², Anna Jablonska², Jiadi Xu^1,2, Yuguo Li^1,2, Martin Pomper², and Peter van Zijl^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

It is desirable to have non-invasive imaging methods able not only to render the expression and distribution of receptors, enzymes and other targets relevant to cancer, but also have a safety profile enabling use as a screening tool. We have developed an enzyme-targeted MR imaging approach that uses non-metallic, non-radioactive dextran as the imaging agent detected by CEST MRI. Our results indicate that imaging tumors expressing the prostate-specific membrane antigen (PSMA) could be accomplished using urea-conjugated dextran particles that could be detected in micromolar (per particle) concentration by MRI.

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