Meeting Banner
Abstract #0733

CEST MRI of PSMA expression using natural dextran-based contrast agents

Guanshu Liu1,2, Sangeeta Ray Banerjee2, Xing Yang2, Nirbhay Yadav1, Ala Lisok2, Anna Jablonska2, Jiadi Xu1,2, Yuguo Li1,2, Martin Pomper2, and Peter van Zijl1,2

1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

It is desirable to have non-invasive imaging methods able not only to render the expression and distribution of receptors, enzymes and other targets relevant to cancer, but also have a safety profile enabling use as a screening tool. We have developed an enzyme-targeted MR imaging approach that uses non-metallic, non-radioactive dextran as the imaging agent detected by CEST MRI. Our results indicate that imaging tumors expressing the prostate-specific membrane antigen (PSMA) could be accomplished using urea-conjugated dextran particles that could be detected in micromolar (per particle) concentration by MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here