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Abstract #0732

Chitin and dibutyrylchitin nanoparticles as imaging enabled vaccine nanocarriers

Barbara Blanco Fernandez1, Yasser A Aldhamen2, Shatadru Chakravarty1, Andrea Amalfitano2, and Erik M Shapiro1

1Radiology, Michigan State University, East Lansing, MI, United States, 2Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States

We describe a strategy for fabricating chitin and dibutyrylchitin –an organo-soluble chitin derivative- nanoparticles (NPs) encapsulating a model antigen (ovalbumin) or iron oxide nanocrystals. The use of MRI enabled the determination of the cell migration of vaccinated cells, allowing the determination of the immunization efficiency in early stages. To form DBC, a reversible acylation of chitin was performed and NPs were fabricated using an emulsification/evaporation method, then chitin was regenerated by alkaline saponification. NPs had vaccine adjuvant properties and allowed the track of immune cells to lymph nodes, proving their utility as vaccine adjuvants and imaging agents.

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