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Abstract #0731

Molecular MR imaging of renal fibrogenesis in a mouse model

Philip Alan Waghorn1, Iris Chen1, Nicholas Rotile1, Chloe Jones1, Diego Ferreira1, Lan Wei2, Bryan Fuchs2, and Peter Caravan1

1A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Division of Surgery, Massachusetts General Hospital, Boston, MA, United States

The fibrotic deposition and remodeling of extracellular matrix (ECM) proteins to form cross-linked collagen and elastin fibers is a characteristic feature of chronic kidney disease (CKD). Critical to fiber formation is the presence of allysine, which facilitates fibril cross-linking through condensation reactions with neighboring allysine and lysine residues on collagen and elastin. We have developed a novel Gd-based MR probe, GdOA, designed to target allysine for non-invasive molecular imaging of active fibrogenesis in kidney disease, allowing the onset of fibrogenesis to be detected and provide a quantitative measure of the efficacy of future anti-fibrotic targeted therapies.

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