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Abstract #0787

Diffusion imaging in grade II and III gliomas depends upon new vs recurrent status and enhancing vs nonenhancing status.

Tracy L Luks1, Tracy Richmond McKnight1, Evan Neill1, Llewellyn Lynn Jalbert1, Arie Perry1, Soonmee Cha1, Joanna Phillips1, Annette Molinaro1, Susan Chang1, and Sarah J. Nelson1

1University of California San Francisco, San Francisco, CA, United States

The relationship of diffusion imaging parameters with prognostic histological and molecular factors for patients with grade II and III gliomas is unclear, particularly for tumors that are non-enhancing on post-Gadolinium images. We investigated the relationship of ADC and FA values with histological tumor score, tumor grade, and molecular characteristics for non-enhancing (NE) vs contrast-enhancing (CE) and newly-diagnosed (ND) vs recurrent (REC) disease. In NE patients, histopathological and molecular characteristics associated with poorer clinical outcome were found to have higher ADC and lower FA. In CE patients, some characteristics associated with poorer outcome hadlower ADC and higher FA.

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