The relationship of diffusion imaging parameters with prognostic histological and molecular factors for patients with grade II and III gliomas is unclear, particularly for tumors that are non-enhancing on post-Gadolinium images. We investigated the relationship of ADC and FA values with histological tumor score, tumor grade, and molecular characteristics for non-enhancing (NE) vs contrast-enhancing (CE) and newly-diagnosed (ND) vs recurrent (REC) disease. In NE patients, histopathological and molecular characteristics associated with poorer clinical outcome were found to have higher ADC and lower FA. In CE patients, some characteristics associated with poorer outcome hadlower ADC and higher FA.
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