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Abstract #0788

Prevalence of diffusely abnormal white matter in individuals with clinically isolated syndromes suggestive of multiple sclerosis

Cornelia Laule1,2,3, Jimmy Lee1, Guojun Zhao4,5, Rick White6, Irene M. Vavasour1, Andrew Riddehough4,5, Anthony L. Traboulsee4,5, Luanne Metz7, and David K.B. Li1,4,5

1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, 4Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 5MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada, 6Statistics, University of British Columbia, Vancouver, BC, Canada, 7Medicine, University of Calgary, Calgary, AB, Canada

Diffusely abnormal white matter (DAWM) is present in individuals with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) at a similar frequency as seen in definite MS. CIS subjects with DAWM showed reduced brain volume and greater lesion load, both of which are known to correlate with clinical disability and progression. DAWM may have prognostic importance in CIS so examining its impact on conversion to MS, future disability and progression is warranted.

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