Diffusely abnormal white matter (DAWM) is present in individuals with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) at a similar frequency as seen in definite MS. CIS subjects with DAWM showed reduced brain volume and greater lesion load, both of which are known to correlate with clinical disability and progression. DAWM may have prognostic importance in CIS so examining its impact on conversion to MS, future disability and progression is warranted.
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