Abstract #0789

Decreasing magnetic susceptibility (QSM) of thalamic nuclei in Multiple Sclerosis (MS) – the thalamus as a target of projected inflammation?

Ferdinand Schweser^1,2, Ana Luiza Raffaini Duaete Martins¹, Fuchun Lin¹, Jesper Hagemeier¹, Jannis Hanspach¹, Bianca Weinstock-Guttman³, Nicola Bertolino¹, Dhaval Shah¹, Niels P Bergsland^1,4, Michael G Dwyer¹, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ⁴MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy

This work studied intra-thalamic magnetic susceptibility changes in 120 patients with clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and secondary progressive MS (SPMS). We detected decreased magnetic susceptibility in several nuclear groups of the thalamus in MS patients compared to controls, indicative of decreased iron concentration.

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