In this work, a new approach for looking at the “iron deposition” in deep gray matter is presented. We investigated iron deposition in the deep gray matter indirectly by measuring R2*. In addition, we assessed the normalized volume of the structures of the DGM. We found a stronger association between increases in R2* and volume reductions of the same DGM structures in the MS group compared with the control group. Finally, we corrected the R2* measurements by the volume of the structures (R2*m). The R2*m values were reduced in the MS group suggesting that iron accumulation is not a common feature of MS but on the contrary a redistribution/reduction of the iron takes place, which may be masked by structural atrophy.