Spinal cord injury (SCI) leads to neuronal cell death, axonal damage and demyelination. Brain undergo anatomical changes following SCI. Recently MR phase imaging has shown promising application in visualizing demyelination. In this study we explored the possibility to investigate integrity of cranial corticospinal tract in SCI using phase imaging. Diffusion tensor imaging was also used to verify the axonal integrity. The results showed phase contrast decreased along with axial diffusivity did not significantly change in contralateral pyramid two weeks post-injury compared to pre-injury levels. Thus, phase imaging is a potential endogenous biomarker for brain axonal integrity after SCI.
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