Abstract #0795

Spatial and Temporal Relationship between Microstructural and Morphological Abnormalities of Alzheimer’s disease: Evidence in Cortical and Deep Gray Matter

Nan-Jie Gong^1,2, Chun-Chung Chan³, Lam-Ming Leung³, Chun-Sing Wong⁴, Russell Dibb⁵, and Chunlei Liu^5,6

¹University of California Berkeley, Berkeley, CA, United States, ²Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, United States, ³United Christian Hospital, Hong Kong, ⁴The University of Hong Kong, Hong Kong, ⁵Duke University School of Medicine, ⁶Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA, United States

Non-Gaussian diffusion metrics such as MK from DKI can complement conventional MD and FA for detecting microstructural changes, especially in deep gray matter. This can potentially improve the efficacy of diffusion metrics for serving as diagnostic imaging biomarkers. We also provided evidence supporting the proposed notion that microstructural changes in cortical and deep gray matter predate macrostructural changes such as volume and cortical thickness.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.