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Abstract #0800

Measuring Local Pulse Wave Velocity in the Carotid Arteries using a Compressed Sensing reconstruction for high temporal resolution (4 ms) 2D PC CINE MRI

Eva S Peper1, Wouter V Potters2, Abdallah G Motaal3, Pim van Ooij1, Aart J Nederveen1, Gustav J Strijkers4, and Bram F Coolen4

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Neurologie en Klinische Neurofysiologie, Academic Medical Center, Amsterdam, Netherlands, 3Imaging Clinical Applications and Platform, Philips Healthcare, Netherlands, 4Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands

Measuring PWV with MRI would provide a useful tool to measure arterial stiffness locally. However, the limitation of MRI for this implementation is temporal resolution. This study validates a technique to measure local PWV at up to only 5 cm of the carotid arteries using 2D PC CINE MRI data of a high temporal resolution compressed sensing (CS) reconstruction. The method is validated using a pulsatile flow phantom and two groups of 10 elderly and 10 younger healthy volunteers. A significant difference between age groups was found.

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