Abstract #0806

Quantitative assessment of the fetal brain myelination in vivo using fast macromolecular proton fraction mapping

Alexandra M. Korostyshevskaya¹, Irina Yu. Prihod'ko¹, Andrey A. Savelov², and Vasily L. Yarnykh^3,4

¹Medical Diagnostics, International Tomography Center of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, ²International Tomography Center of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, ³Radiology, University of Washington, Seattle, WA, United States, ⁴Tomsk State University, Tomsk, Russian Federation

Macromolecular proton fraction (MPF) is a biophysical parameter describing cross-relaxation and closely correlated with myelin content in neural tissues. This study presents the first evaluation of the fast MPF mapping method in prenatal clinical neuroimaging and suggests that MPF in the fetal brain structures is sensitive to the earliest stages of myelin development.

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