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Abstract #0807

Anatomically constrained tractography and structural connectome of the neonatal brain

Manuel Blesa1, Ahmed Serag1, Devasuda Anblagan1,2, Emma J. Telford1, Sarah A. Sparrow1, Scott I. Semple3, Mark E. Bastin2, and James P. Boardman1,2

1MRC Centre for Reproductive Health, University of Edinburgh, edinburgh, United Kingdom, 2Centre for Clinical Brain Sciences, University of Edinburgh, edinburgh, United Kingdom, 3Clinical Research Imaging Centre, University of Edinburgh, edinburgh, United Kingdom

The Anatomically-Constrained Tractography framework (ACT) is an advanced method to create tractography that relies on very accurate segmentation of the brain. To evaluate its role in tractography of the developing brain, we optimised the pipeline for neonatal data and compared against other methods (FA and WM seeding, with deterministic and probabilistic algorithms) used for the computation of neonatal structural connectivity. The results suggest that ACT with seeding at the GM / WM interface enhances anatomic accuracy of neonatal tractography, compared with other methods, and it has a significant impact on network measures.

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