Abstract #0808

The short-range association fibers underlie brain network reconfiguration in typically and atypically developing children

Minhui Ouyang¹, Jennifer Muller¹, Hua Cheng², Yun Peng², J. Christopher Edgar^1,3, John A. Detre^3,4, Timothy P.L. Roberts^1,3, and Hao Huang^1,3

¹Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, ³Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁴Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Short-range association fibers (SAF) or U-fibers, connect adjacent gyri and constitute the majority of brain white matter. During development, SAF undergo dramatic changes in conjunction with brain network reconfiguration. How SAF reshape the brain network configuration during typical and atypical development is unknown. In this study, SAF was quantified with an index defined as normalized short-range association fibers (NSAF). We found that NSAF decreases were associated with increases in brain network efficiency in the typical developing brain from 2-7 years. Similar association were not observed in children with autism.

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