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Abstract #0809

Multimodal thalamocortical connectivity patterns in early brain development

Silvina Laura Ferradal1, Borjan Gagoski2, Camilo Jaimes Cobos3, Francesca Yi1, Clarissa Carruthers1, Catherine Vu1, Ryan Larsen4, Brad Sutton4, P. Ellen Grant1, and Lilla Zollei3

1Newborn Medicine, Boston Children's Hospital, Boston, MA, United States, 2Radiology, Boston Children's Hospital, Boston, MA, United States, 3Massachussetts General Hospital, Boston, MA, United States, 4University of Illinois at Urbana-Champaign, Urbana, IL, United States

Understanding normal thalamocortical organization in early brain development has significant clinical relevance as it could provide early indicators of neurodevelopmental disorders which could originate from alterations in functional and structural brain maturation. Here we show structural and functional thalamocortical connectivity patterns derived from twenty healthy term infants scanned within the first weeks of life. Our results show that while there is a general good spatial agreement between both modalities, there are certain regions that exhibit different thalamocortical patterns. These discrepancies are possibly mediated by maturational processes such as axonal myelination and synaptogenesis.

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