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Abstract #0814

In vivo measurement of g-ratio in the Corpus Callosum using the macromolecular tissue volume: evaluating changes as a function of Callosal subregions, age and sex.

Shai Berman1, Jason Yeatman2, and Aviv Mezer1

1The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel, 2The Institute for Learning & Brain Sciences and the Department of Speech and Hearing Sciences, The University of Washington, Seattle, WA, USA.

Recent developments in quantitative and diffusion MRI, have made it possible to estimate the axonal g-ratio in human white-matter in-vivo. g-ratio is the ratio between the inner and outer radii of the myelin sheath wrapped around the axon. We suggest a simplified measurement of g-ratio incorporating proton density mapping, and implement it in the Corpus-Callosum of 100 subjects (ages 8-80). We find the g-ratio values agree with previously results. Furthermore, g-ratio values are stable over the lifespan and between the sexes. These results converge with theoretical evidence suggesting g-ratio has an optimal value for white-matter function.

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