Abstract #0815

Greater Relaxivity in Brain Regions Indicates Tissue Iron Deposition in Adolescence to Adulthood

Eric Thomas Peterson¹, Dongjin Kwon¹, Beatriz Luna^2,3,4, Bart Larsen², Devin Prouty¹, Edith Vioni Sullivan⁵, and Adolf Pfefferbaum¹

¹Biosciences, SRI International, Menlo Park, CA, United States, ²Psychlogy, University of Pittsburgh, Pittsburgh, PA, United States, ³Center for the Neural Basis of Cognition, Pittsburgh, PA, United States, ⁴Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ⁵Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

This study investigates non-heme iron deposition in the adolescent brain in specific iron-susceptible regions as a function of age, sex, body mass index, supratentorial brain volume, handedness, scanning site, and race. A large cohort of 531 healthy adolescents, ages 12 to 22 years, were scanned at five sites on GE and Siemens systems using standard DTI and fMRI pulse sequence. This study demonstrates that in bilateral pallidum, putamen, dentate nucleus, red nucleus, and substantia nigra, both T₂ and T₂* show age-related declines. These results suggest ferratin-encapsulated iron deposition in specific brain regions is associated with normal adolescent brain development.

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