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Abstract #0815

Greater Relaxivity in Brain Regions Indicates Tissue Iron Deposition in Adolescence to Adulthood

Eric Thomas Peterson1, Dongjin Kwon1, Beatriz Luna2,3,4, Bart Larsen2, Devin Prouty1, Edith Vioni Sullivan5, and Adolf Pfefferbaum1

1Biosciences, SRI International, Menlo Park, CA, United States, 2Psychlogy, University of Pittsburgh, Pittsburgh, PA, United States, 3Center for the Neural Basis of Cognition, Pittsburgh, PA, United States, 4Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 5Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

This study investigates non-heme iron deposition in the adolescent brain in specific iron-susceptible regions as a function of age, sex, body mass index, supratentorial brain volume, handedness, scanning site, and race. A large cohort of 531 healthy adolescents, ages 12 to 22 years, were scanned at five sites on GE and Siemens systems using standard DTI and fMRI pulse sequence. This study demonstrates that in bilateral pallidum, putamen, dentate nucleus, red nucleus, and substantia nigra, both T2 and T2* show age-related declines. These results suggest ferratin-encapsulated iron deposition in specific brain regions is associated with normal adolescent brain development.

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