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Abstract #0820

Using Cardiorenal MRI to assess fluid balance

Chris Bradley1,2, Damian Bragg2, Eleanor F Cox1,2, Ahmed M El-Sharkawy2, Abeed H Chowdhury2, Dileep N Lobo2, and Susan T Francis1,2

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom

We used quantitative MRI measurements to perform a randomised, double-blind crossover study on the effects of isovolumetric and isoeffective infusions of colloid versus crystalloid on structural and haemodynamic (ASL, ADC, flow, volume) changes in the kidney and cardiac output. No significant differences were observed between the blood expanding properties of the infusions, despite using a colloid infusion one-third the volume of the reference crystalloid infusion. We observed a trend of less oedema using an isoeffective volume of colloid. Repeated MRI measurements demonstrated low CoVs, allowing MRI to assess subtle changes in structure and haemodynamics for determining optimal perioperative infusions.

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