Abstract #0819

In vivo multifrequency MR elastography for the assessment of renal stiffness in patients with IgA nephropathy

Jing Guo¹, Stephan Marticorena Garcia ¹, Michael Dürr², Florian Dittmann¹, Sebastian Hirsch¹, Jürgen Braun³, and Ingolf Sack¹

¹Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Renal stiffness was investigated using multifrequency MRE in healthy controls and patients with IgA nephropathy. Patients show a reduced renal stiffness as compared to healthy controls. DWI and BOLD imaging were also applied to the subjects. Both ADC and T2* were linearly correlated with wave speed obtained from MRE. By mechanical vascular-solid tissue interactions, wave speed measurements by multifrequency MRE offer a quantitative measure for the noninvasive assessment renal function.

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