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Abstract #0819

In vivo multifrequency MR elastography for the assessment of renal stiffness in patients with IgA nephropathy

Jing Guo1, Stephan Marticorena Garcia 1, Michael Dürr2, Florian Dittmann1, Sebastian Hirsch1, Jürgen Braun3, and Ingolf Sack1

1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Renal stiffness was investigated using multifrequency MRE in healthy controls and patients with IgA nephropathy. Patients show a reduced renal stiffness as compared to healthy controls. DWI and BOLD imaging were also applied to the subjects. Both ADC and T2* were linearly correlated with wave speed obtained from MRE. By mechanical vascular-solid tissue interactions, wave speed measurements by multifrequency MRE offer a quantitative measure for the noninvasive assessment renal function.

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