Abstract #0824

Dynamic Contrast-enhanced MRI in Renal Tumors: Common Subtype Differentiation using Pharmacokinetics

Haiyi Wang¹, Lu Ma¹, Zihua Su², Ning Huang², Xiao Xu³, Zhipeng Sun⁴, Aitao Guo⁵, and Huiyi Ye¹

¹Department of Radiology, Chinese PLA General Hospital, Beijing, People's Republic of China, ²Lift Science, Advanced Application Team, GE Healthcare China, Beijing, People's Republic of China, ³Lift Science, Advanced Application Team, GE Healthcare China, Shanghai, People's Republic of China, ⁴Department of Radiology, No.1 Hospital of Zhangjiakou, Zhangjiakou, People's Republic of China, ⁵Department of Pathology, Chinese PLA General Hospital, Beijing, People's Republic of China

Synopsis

In this prospective study on pharmacokinetic parameters (K^trans & V_e) of renal tumors, we enrolled the patients with five common subtypes of renal tumor - clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), chromophobic renal cell carcinoma (cRCC), uroepithelial carcinoma (UEC), and fat poor angiomyolipoma (fpAML) to undergo DCE-MRI pharmacokinetic studies. Our results demonstrated that ccRCC, pRCC, cRCC, UEC and fpAML are pharmacokinetically different (K^trans & V_e). K^trans could distinguish ccRCC from non-ccRCC (pRCC & cRCC) and differentiate fpAML with non-ccRCC with high specificity and sensitivity, which probably can facilitate the precise treatment of renal tumors in the future clinical practice.

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