Abstract #0842

Diffusion time dependence of kurtosis reveals microstructural changes after neonatal hypoxia-ischemia

Dan Wu¹, Frances J Northington², Els Fieremans³, Dmitry Novikov³, and Jiangyang Zhang³

¹Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiology, New York University School of Medicine, NY, United States

Apparent diffusion coefficient (ADC) and diffusion kurtosis are both sensitive markers to ischemic brain injury. We investigated the diffusion time (t_d)-dependency of ADC and kurtosis at nine t_d’s ranging from 2.5 to 60 ms in a mouse model of neonatal hypoxic-ischemic injury. In the hippocampus, ADCs showed a monotonous decrease with increasing t_d, whereas kurtosis reached its maximum at t_d of 5-10 ms and decreased for longer t_d’s . At the shortest t_d in this study, we found significant increased kurtosis in the edema region but no significant reduction in diffusivity, suggesting their different sensitivities to microstructural changes after ischemic injury.

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