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Abstract #0842

Diffusion time dependence of kurtosis reveals microstructural changes after neonatal hypoxia-ischemia

Dan Wu1, Frances J Northington2, Els Fieremans3, Dmitry Novikov3, and Jiangyang Zhang3

1Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Radiology, New York University School of Medicine, NY, United States

Apparent diffusion coefficient (ADC) and diffusion kurtosis are both sensitive markers to ischemic brain injury. We investigated the diffusion time (td)-dependency of ADC and kurtosis at nine td’s ranging from 2.5 to 60 ms in a mouse model of neonatal hypoxic-ischemic injury. In the hippocampus, ADCs showed a monotonous decrease with increasing td, whereas kurtosis reached its maximum at td of 5-10 ms and decreased for longer td’s . At the shortest td in this study, we found significant increased kurtosis in the edema region but no significant reduction in diffusivity, suggesting their different sensitivities to microstructural changes after ischemic injury.

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