Abstract #0841

Time Dependence Of White Matter Biomarkers From Axially Symmetric Diffusion Kurtosis Imaging

Jonas Lynge Olsen¹, Brian Hansen², Noam Shemesh³, and Sune Nørhøj Jespersen^1,2

¹Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark, ²CFIN/MINDLab at the Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

Using a recently developed PFG-based framework for fast diffusion kurtosis imaging we observe a strong time dependence of diffusion and kurtosis metrics in fixed spinal cord white matter from 6-350 ms. DKI metrics can be expressed in terms of intra- and extra axonal properties using white matter tract integrity (biexponential modelling), but a sign ambiguity results in two solutions of the inverse problem. The time dependence of the two solutions observed here help identify the correct solution, and allows comparing time-dependent compartment diffusivities with theory.

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