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Abstract #0841

Time Dependence Of White Matter Biomarkers From Axially Symmetric Diffusion Kurtosis Imaging

Jonas Lynge Olsen1, Brian Hansen2, Noam Shemesh3, and Sune Nørhøj Jespersen1,2

1Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark, 2CFIN/MINDLab at the Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

Using a recently developed PFG-based framework for fast diffusion kurtosis imaging we observe a strong time dependence of diffusion and kurtosis metrics in fixed spinal cord white matter from 6-350 ms. DKI metrics can be expressed in terms of intra- and extra axonal properties using white matter tract integrity (biexponential modelling), but a sign ambiguity results in two solutions of the inverse problem. The time dependence of the two solutions observed here help identify the correct solution, and allows comparing time-dependent compartment diffusivities with theory.

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