Meeting Banner
Abstract #0856

Characterization of in vivo Chemical Exchange Parameters Using Chemical Exchange-Sensitive MRI at 9.4 T and 15.2 T

Julius Juhyun Chung1,2, Wonmin Choi1,3, Tao Jin4, Jung Hee Lee1,2,3,5, and Seong-Gi Kim1,2,3

1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Samsung Advanced Insitute for Health Sciences and Technology, SKKU, Seoul, Korea, Republic of, 3Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 4Radiology, University of Pittsburgh, 5Radiology, Sungkyunkwan University, Seoul, Korea, Republic of

Chemical-exchange sensitive imaging can prove to be complex particularly when imaging intermediate exchanges in-vivo where contrast comes from an amalgamation of different sources. We propose a method that utilizes Z-spectra data from multiple fields to determine apparent exchange parameters that characterize the exchange to which a particular saturation scheme is sensitive. Parameter determination in glutamate phantoms proved commensurate to utilizing an on-resonance dispersion measurement and in the rat brain cortex the kex was measured to be 11,240 s-1 antemortem and 7070 s-1 postmortem. This method is useful for determining exchange parameters relevant to complex systems when signal source is unclear.

This abstract and the presentation materials are available to members only; a login is required.

Join Here