Chemical-exchange sensitive imaging can prove to be complex particularly when imaging intermediate exchanges in-vivo where contrast comes from an amalgamation of different sources. We propose a method that utilizes Z-spectra data from multiple fields to determine apparent exchange parameters that characterize the exchange to which a particular saturation scheme is sensitive. Parameter determination in glutamate phantoms proved commensurate to utilizing an on-resonance dispersion measurement and in the rat brain cortex the kex was measured to be 11,240 s-1 antemortem and 7070 s-1 postmortem. This method is useful for determining exchange parameters relevant to complex systems when signal source is unclear.
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