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Abstract #0857

Improving Amide Proton Transfer (APT) MRI Quantification in Acute Human Stroke Patients: Achieving More Pure APT Signals and Higher Detection Sensitivity

Hye-Young Heo1,2, Yi Zhang1, Tina Burton3, Shanshan Jiang1, Peter C.M. van Zijl1,2, Richard Leigh3, and Jinyuan Zhou1,2

1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, United States

APT-weighted (APTw) imaging based on MTR asymmetry analysis has shown promise for identifying ischemic lesions, but suffers from low accuracy due to small APTw intensity changes, Quantitative APT, nuclear overhauser enhancement (NOE), perfusion and diffusion MRI were performed on acute stroke patients (n=30). The results showed that while APTw MRI for pH analysis based on MTRasym analysis was confounded by upfield NOE effects, NOE-free APT-MRI contrast between normal and ischemic lesions was substantially increased, nearly 3 times larger than that based on MTRasym analysis. Furthermore, noticeable NOE contrast was observed for lesions, explained in terms of a relayed-NOE transfer mechanism.

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