Abstract #0858

Spatiotemporal quantification of reporter gene expression in the mouse heart using the Lysine Rich Protein and cardiac chemical exchange saturation transfer

Shelby Meier¹, Jose Abisambra², J Brandon³, Assaf Gilad⁴, and Moriel Vandsburger^1,5

¹Physiology, University of Kentucky, Lexington, KY, United States, ²Physiology, University of Kentucky, ³University of Kentucky, ⁴Radiology and Radiological Sciences, Johns Hopkins University, ⁵Bioengineering, U.C. Berkeley, Berkeley, CA, United States

We utilized cardiac chemical exchange saturation transfer MRI and an artificial reporter gene, the Lysine Rich Protein (LRP), to image gene transfer in the mouse heart using 2 routes of viral vector administration.

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