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Abstract #0859

T1ρ-weighted Dynamic Glucose Enhanced MRI

Patrick Schuenke1, Daniel Paech1, Christina Koehler1,2, Johannes Windschuh1, Peter Bachert1, Mark E. Ladd1, Heinz-Peter Schlemmer1, Alexander Radbruch1,2, and Moritz Zaiss3

1German Cancer Research Center (DKFZ), Heidelberg, Germany, 2University Hospital Heidelberg, Heidelberg, Germany, 3Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany

Natural D-glucose can serve as a biodegradable contrast agent for the detection of tumors by means of Chemical Exchange Saturation Transfer (CEST) or Chemical Exchange sensitive Spin-Lock (CESL) Dynamic Glucose Enhanced (DGE) MRI. For application of CESL-based DGE-MRI at a 7T whole-body scanner, we implemented an adiabatic CESL sequence and essentially increased the temporal resolution employing a T-weighted acquisition scheme. Further, we introduced a simple, robust and quantitative DGE contrast. First application of T-weighted DGE-MRI in a glioblastoma patient provided a substantial contrast between tumor and healthy brain tissue and showed the dynamic glucose enhancement after a glucose bolus injection.

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