Abstract #0859

T1ρ-weighted Dynamic Glucose Enhanced MRI

Patrick Schuenke¹, Daniel Paech¹, Christina Koehler^1,2, Johannes Windschuh¹, Peter Bachert¹, Mark E. Ladd¹, Heinz-Peter Schlemmer¹, Alexander Radbruch^1,2, and Moritz Zaiss³

¹German Cancer Research Center (DKFZ), Heidelberg, Germany, ²University Hospital Heidelberg, Heidelberg, Germany, ³Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany

Natural D-glucose can serve as a biodegradable contrast agent for the detection of tumors by means of Chemical Exchange Saturation Transfer (CEST) or Chemical Exchange sensitive Spin-Lock (CESL) Dynamic Glucose Enhanced (DGE) MRI. For application of CESL-based DGE-MRI at a 7T whole-body scanner, we implemented an adiabatic CESL sequence and essentially increased the temporal resolution employing a T_1ρ-weighted acquisition scheme. Further, we introduced a simple, robust and quantitative DGE contrast. First application of T_1ρ-weighted DGE-MRI in a glioblastoma patient provided a substantial contrast between tumor and healthy brain tissue and showed the dynamic glucose enhancement after a glucose bolus injection.

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