Abstract #0872

The value of diffusion kurtosis imaging in assessing pathological complete response to neoadjuvant chemoradiation therapy in rectal cancer: a comparison with conventional diffusion-weighted imaging

Fei-Xiang Hu¹, Tong Tong¹, Wei Tang¹, Yi-Qun Sun¹, Dang Wang¹, San-Jun Cai², Zhen Zhang³, Grimm Robert⁴, Xu Yan⁵, Cai-xia Fu⁶, and Wei-Jun Peng¹

¹Radiology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, ²Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, ³Radiotherapy, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, ⁴MR Applications Predevelopment, Siemens Healthcare GmbH, Germany, ⁵MR Collaboration NE Asia, Siemens Healthcare, People's Republic of China, ⁶APPL, Siemens Shenzhen Magnetic Resonance Ltd., People's Republic of China

The aim of this study was to evaluate the performance of diffusion kurtosis imaging (DKI) in predicting pathological complete response (pCR) of locally advanced rectal cancer (LARC) to neoadjuvant chemoradiation therapy (CRT) before and at an early stage of the treatment, and in comparison to conventional diffusion-weighted imaging (DWI). Results showed that DKI outperformed conventional DWI in accurately differentiating between pCR and nonPCR patients who received neoadjuvant chemoradiation therapy both before and at an early stage of treatment.

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