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Abstract #0872

The value of diffusion kurtosis imaging in assessing pathological complete response to neoadjuvant chemoradiation therapy in rectal cancer: a comparison with conventional diffusion-weighted imaging

Fei-Xiang Hu1, Tong Tong1, Wei Tang1, Yi-Qun Sun1, Dang Wang1, San-Jun Cai2, Zhen Zhang3, Grimm Robert4, Xu Yan5, Cai-xia Fu6, and Wei-Jun Peng1

1Radiology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, 2Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, 3Radiotherapy, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, 4MR Applications Predevelopment, Siemens Healthcare GmbH, Germany, 5MR Collaboration NE Asia, Siemens Healthcare, People's Republic of China, 6APPL, Siemens Shenzhen Magnetic Resonance Ltd., People's Republic of China

The aim of this study was to evaluate the performance of diffusion kurtosis imaging (DKI) in predicting pathological complete response (pCR) of locally advanced rectal cancer (LARC) to neoadjuvant chemoradiation therapy (CRT) before and at an early stage of the treatment, and in comparison to conventional diffusion-weighted imaging (DWI). Results showed that DKI outperformed conventional DWI in accurately differentiating between pCR and nonPCR patients who received neoadjuvant chemoradiation therapy both before and at an early stage of treatment.

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Abstract