To explore the ability of IVIM parameters derived from iZoom DWI in differentiating malignant thyroid nodules from benign ones. 40 patients with 45 pathologically proven thyroid nodules were involved. iZOOM DWI with 2D RF was employed to decrease the distortion and carotid coil was used to increase the SNR. 3D ROI was drawn manually to cover the whole lesion. D and f values were significantly lower in malignant nodules than in benign nodules. According to ROC curve analysis IVIM almost reached the upper limit of the accuracy based on US.