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Abstract #0888

Metabolic variability in a brief status epilepticus model

Jullie W Pan1, Yijen Wu2, Patrice Pearce3, Nihal de Lanerolle4, and Kevin Kelly5

1MRRC, University of Pittsburgh, Pittsburgh, PA, United States, 2Developmental Biology, Children's Hospital Pittsburgh, Pittsburgh, PA, 3Neurology, University of Pittsburgh, Pittsburgh, PA, 4Neurosurgery, Yale University, 5Allegheny Singer Research Institute, Pittsburgh, PA

This study uses short echo MR spectroscopy (TE 10ms) to study the metabolic changes seen in a status epilepticus kainate rodent model. Applied with a brief period (45min) of seizures, a hierarchical cluster analysis is performed on the spectroscopic changes measured 3days after the status injury. These data displayed a bimodal distribution characterizing two groups of animals, “more” or “less” injured. The classification persists into a repeat MRS measurement performed at 3wk, with the less injured group being able to recover; the more injured group did not recover well. Finally, this classification was consistent with Nissl based histological analysis.

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