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Abstract #0889

Polyunsaturated fatty acid (PUFA) is associated with tumour grading – An ex vivo study on whole breast tumours using multiple quantum coherence (MQC) MRS

Sai Man Cheung1, Ehab Husain2,3, Yazan Masannat3,4, Klaus Wahle3,5, Steven D Heys3,4, and Jiabao He1

1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, 4Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 5Strathclyde Institute of Pharmacy and Biological Sciences, Glasgow, United Kingdom

Eicosanoids are derivatives of three different PUFA, vital in membrane formation and anti-inflammatory control. The presence of eicosanoids in adipose tissue and fibroblasts governs the release of signalling agents in breast, stimulating the invasion of breast cancer cells. Lipid composition has emerged as a potential predictor of breast cancer. However, current research focuses on the tumour initiation, while the understanding of lipid function in tumour progression remains sparse. We therefore hypothesise that there is a difference in PUFA concentration between grade II and III breast cancer. We applied MQC MRS for accurate PUFA measurement on freshly excised whole breast tumours.

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