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Abstract #0890

In-Vivo Regional detection of Gly in Human Brain: Implications in Glioma Patients at 3T

Vivek Tiwari1, Zhongxu An1, Sandeep Kumar Ganji1, and Changho Choi1

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Glycine, an inhibitory-neurotransmitter and a co-agonist of N-Methyl-D-aspartate, has been implicated in rapid cancer cell-proliferation and is elevated in high-grade gliomas than low-grade. Gly concentrations range from 0.5-1.0 M in normal brain and exhibits regional-variation. Given such a low in-vivo concentration of Gly, potential overlap from mI and regional-variation, here we have developed a novel Gly-optimized single-voxel-localized triple-refocusing scheme for precise co-detection of Gly and mI in Gray-matter (GM)-rich Medial-Occipital (MO) and White-matter (WM) rich Left-Parietal (LP) healthy-brain region, and further extended to measure glycine level in glioma patients.

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