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Abstract #0891

Differential diagnosis of Hepatic metabolites between non-alcoholic steatohepatitis and simple steatosis in humans and a murine model using a 1H MR spectroscopy study with long TE

Tae-Hoon Kim1, Hong Young Jun1, Chang-Won Jeong1, Jong-Hyun Ryu1, Kou Gyeom Kim1, and Kwon-Ha Yoon2

1Radiology, Imaging Science Research Center, Iksan, Korea, Republic of, 2Radiology, Wonkwang University School of Medicine, Iksan, Korea, Republic of

Liver biopsy is the gold standard for diagnosing non-alcoholic fatty liver disease(NAFLD) but with practical constraints. MR spectroscopy(MRS) allows in vivo assessment of hepatocellular metabolism and has shown potential for biochemical differentiation in diffuse liver disease. Recent 13C-MRS demonstrated that alanine and lactate levels in inflammatory liver injury were increased compared to those in normal liver, and these changes were positively correlated with liver enzyme levels. However, the clinical use of 13C-MRS technique is limited because it necessitates 13C-resonance specific hardwares and softwares for data acquisition. This study used long TE 1H-MRS to monitor changes of hepatocellular metabolites in NAFLD.

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