Preterm birth is closely associated with diffuse white matter injury which contributes to long term neurocognitive impairment among survivors. Fixel-based analysis (FBA) is the study of specific fibre populations within a voxel; it provides measures of fibre bundle morphology by combining information about fibre density with structure. In this work, we applied FBA to neonatal dMRI data and provide proof-of-concept that fibre density and fibre bundle cross section may be useful measures for evaluating alterations to brain development associated with preterm birth.
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