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Abstract #0896

Identifying cerebral endophenotypes with associated clinical risk factors in preterm neonates

Gareth Ball1,2, Paul Aljabar1, Shona Falconer1, Andrew T. M Chew1, Nicholas Harper1, Chiara Nosarti1, Mary A Rutherford1, Serena J Counsell1, and A. David Edwards1

1Centre for the Developing Brain, Division of Imaging Sciences and Bioengineering, King's College London, London, United Kingdom, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia

In this study, we combine multimodal neuroimaging and multivariate statistical analysis in a large cohort of preterm infants at term-equivalent age. We report a set of orthogonal imaging phenotypes associated with specific antenatal and postnatal factors that correlate with cognitive and motor outcomes at 2 years. We conclude that contemporaneous environmental factors including adverse intrauterine conditions and postnatal clinical management may prefigure the high incidence of neurocognitive impairment in preterm-born individuals via the cumulative expression of distinct diffuse injury patterns.

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