Abstract #0897

Thyroxine Treatment in Preterms with Grade III/IV Hemorrhage and Microstructural White Matter Assessment with Diffusion Tensor Imaging: A Pilot Study

Vincent Kyu Lee^1,2, Ashok Panigrahy^1,2, and Praveen Ballabh^3,4

¹Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ²Radiology, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, ³Pediatrics (Neonatology), Albert Einstein College of Medicine, New York, NY, United States, ⁴Neuroscience, Albert Einstein College of Medicine, New York, NY, United States

Intraventricular hemorrhage (IVH) in preterm infants is a complication that leads to neurodevelopmental delay and neurologic disorders. In this study we used diffusion tensor imaging (DTI) to analyze the myelination and structural integrity of white matter in preterms with and without T4 treatment using a manual uniform region of interest based analysis and semi-automated method of tractography. This small cohort pilot study of preterm subjects with Grade III-IV IVH demonstrated that thyroxine therapy may result in improved microstructural changes in certain tracts, and DTI maybe able to serve as neuroimaging biomarker for treatment efficacy in relation to thyroxine intervention.

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