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Abstract #0899

Brain metabolic rate, but not perfusion or brain volume, predicts clinical scores in newborns at risk for brain injury

Peiying Liu1, Ying Qi2, Zixuan Lin1, Kaining Shi3, Qiyong Guo2, Xiaoming Wang2, and Hanzhang Lu1

1Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Radiology, Shengjing hospital of China Medical University, Shenyang, People's Republic of China, 3Imaging Systems Clinical Science, Philips Healthcare, Beijing, People's Republic of China

Hypoxic brain injury due to perinatal oxygen deprivation is one of the leading reasons of neonatal death and long-term disabilities. In this study, we evaluated the predictive values of cerebral blood flow (CBF), oxygen extraction fraction (OEF), cerebral oxygen metabolism (CMRO2), and brain volume as biomarkers in the assessment of hypoxic brain injuries in neonatal patients. Our results showed that among these biomarkers, only CMRO2 was significantly associated with Apgar score, which is the standard clinical score indicating the risks of prenatal and perinatal brain injuries. CBF and brain volume increase with age, but have no relationship with Apgar score.

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