Most technical failures of GRE-based MR elastography are related to iron overload, especially at 3.0 T. SE-EPI-based MR elastography may be a useful alternative. 3.0 T GRE and SE-EPI MR elastography sequences were compared in 20 patients with iron overload (mean R2* 114 sec-1) in terms of quantitative liver stiffness (LS) and image quality score (IQS), based on wave propagation and confidence mask coverage, as determined by two experienced radiologists. LS measurements were not significantly different between the two sequences. SE-EPI showed a trend toward higher confidence mask coverage and significantly higher IQS for both readers compared to GRE.
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